Post-industrial neighbourhood east of the Florenc station, rebuilt after the 2002 floods. Eska, Stangl, Antonin Bakery and Muj Salek Kavy live here.
Eska in Karlin holds a Michelin Bib Gourmand. The Ambiente group rebuilt a 19th-century Karlin factory into a bakery-restaurant cooking modern Czech.
Signature: Old bread sourdough, Fermented potato
Order: Old bread with butter, then the kitchen's daily fermentation.
Stangl took a Michelin star plus a Green Star in the 2025 guide. Located in Karlin. Order the the five-course tasting; book the saturday breakfast version.
Order: The five-course tasting; book the Saturday breakfast version.
Eska is the Ambiente group's Karlin bakery-restaurant, holding a Michelin Bib Gourmand and serving a Czech-rooted modern menu from a converted 19th-century.
Order: Old bread sourdough with butter, then the fermented potato dish.
Lokal Hamburk is the Karlin outpost of the Ambiente pub chain, on the site of a 19th-century river-harbour inn. Order the vepro-knedlo-zelo; pour from tank.
Signature: Vepro-knedlo-zelo, Tank Pilsner
Order: Vepro-knedlo-zelo; pour from tank.
Muj Salek Kavy translates as my cup of coffee. Located in Karlin. Order the doubleshot espresso. Counter seating and table service available.
Signature drink: Doubleshot espresso
Tip: Reservations save the day at brunch; the breakfast plate is the kitchen's tightest.
Eska Karlin is the original Ambiente bakery-cafe-restaurant in a converted 19th-century factory. Open mon-fri 08:00-22:00, sat-sun 09:00-22:00.
Signature drink: Black filter
Tip: The Stangl tasting room is upstairs; book in advance for that experience.
Eska's Karlin bakery counter sells bread 33, the city's most cited sourdough, plus kolache and laminated pastries. At Pernerova 49. Booking recommended.
Tip: Bread 33 sells out by lunch on Saturday; sweet kolache last longer.
Worth the queue: Bread 33, three-stage rye on beech wood
Antoninovo Pekarstvi opened the first of its six city-wide bakeries in Karlin in 2014. Wheat-rye and potato sourdough loaves, all baked on-site.
Tip: The decorated chlebicky are made up at the counter; ask for a flight to-go.
Worth the queue: Potato sourdough loaf
Alf and Bet roasts specialty coffee and bakes artisan bread out of an old industrial workshop in Liben-Karlin. Open mon-fri 09:00-18:00. At Krizikova 488/115.
Tip: Order through EMA espresso bars rather than visiting the roastery directly.
Sources from: Ethiopia, Brazil, Guatemala, Rwanda
How they serve: Espresso, Filter, Whole bean retail, Subscription
EMA's Karlin cafe doubles as their main Prague specialty coffee shopfront. Beans roasted by partner Alf and Bet are served with fresh bread.
Tip: The Florenc original is closer to public transport; same beans, smaller crowd.
Sources from: Ethiopia, Colombia, Rwanda
How they serve: Espresso, Filter, Whole bean retail
Veltlin in Karlin is Bogdan Trojak's natural-wine bar, focused on what he calls authentic wines from the old Habsburg empire. Open tue-sat 17:00-23:00.
Signature pour: Moravian pet-nat by the glass
Wine focus: Authentic wines from the former Habsburg empire, Moravia heavy
Food: Cheese, sardines, small plates
Tip: Trust the staff; ask for a Moravian flight and order the sardines.
Lokal Hamburk in Karlin is the river-harbour-themed Ambiente Lokal, the most neighbourhood-feeling of the chain. Order the tank pilsner urquell.
Signature drink: Tank Pilsner Urquell
Food: Czech pub menu
Tip: The terrace seats in summer go fast; book ahead Friday onward.
Kasarna Karlin's gravel courtyard runs the Fousac burger truck alongside seasonal food-truck rotations, with several bar shacks around the perimeter.
Try: Fousac burgers and rotating courtyard food trucks
Tip: Fousac usually sells out before 19:00 on warm days; weekday lunch shifts are calmer than the after-work crowd.
Dva Kohouti in Karlin is the Ambiente group's brewery joint-venture with Matuska. The 12-degree lager is the house pour; the back beer garden in summer.
Tip: The 12-degree lager is the house pour; the back beer garden in summer.
Kasarna Karlin is a former military barracks turned all-day food and drinks courtyard, reopened in 2025 after a zoning standoff. At Prvniho pluku 20/2.
Tip: Bring layers; the kitchen wraps when it rains.
The Karlin Street Food Festival is the city's largest one-day street food fair, an annual neighbourhood event on Karlinske namesti with around 40 food stalls.
Tip: Cashless; come hungry, stalls are tightly packed, plates designed to share.
Antoninovo Pekarstvi's Karlin bakery sells made-up chlebicky at 45 $ each plus daily soups. Two chlebicky plus a soup is lunch for under 200 $.
Try: Three chlebicky plus soup
Tip: Sit at the counter with a coffee; the egg-and-beetroot pair is the smart order.
Muj Salek Kavy in Karlin is the Doubleshot-run brunch spot Prague locals book ahead. Egg dishes, the daily pastry, single-origin filter coffee.
Order: House breakfast plate with single-origin pour
Tip: Reservations save the day; the breakfast plate is the kitchen's tightest piece.
Eska Karlin runs an all-day brunch in the bakery-restaurant: bread 33 sourdough toast, eggs, fermented vegetables and the kitchen's morning pastry plate.
Order: Bread 33 toast, eggs, fermented Czech vegetables
Tip: Book Saturday brunch in advance; bread 33 sells out by noon weekly.
Cloud 9 sits on the ninth-floor roof of the Hilton Prague at the edge of Karlín, with a 360-degree view across the Vltava to the Castle, Old Town and Žižkov tower. The cocktail list runs gin-and-tonic builds plus classic spirits, paired with small sharing plates from the hotel kitchen.
Tip: Hotel-guest priority; book a window seat via SevenRooms. Closing at 23:00 means arrive before 21:00 for a long sit.