Cross Club fills a labyrinth of rooms in a Holešovice industrial building near Nádraží Holešovice, with sculpted scrap-metal interiors and a programme of drum and bass, dubstep, techno and live alternative acts across two stages. The cafe upstairs runs all day; the underground club opens nightly from 20:00.
Tip: The smaller second stage opens earlier than the main floor. Tram or metro C to Nádraží Holešovice is two minutes away; cash bar.
Address: Plynární 1096/23, 170 00 Praha 7, Prague
Mecca opened in 1998 in a former Holešovice factory and runs three floors with two music stages and five bars, programming house and techno on the main floor and broader hip-hop and pop on the smaller stages. Open on event weekends rather than nightly.
Tip: Tram to Dělnická is the easy way in. Programming is event-driven so check mecca.cz before turning up.
Roxy occupies a vaulted Old Town cellar on Dlouhá and has booked Prague's longest-running electronic music programme since 1992, alongside live indie and rock shows in a four-bar room beneath medieval brick arches. Bookings run from local residents to international touring DJs.
Tip: Tickets on GoOut; the queue moves fastest before midnight. The NoD theatre upstairs runs separate programming.
Mecca opened in 1998 in a former Holešovice factory and runs three floors with two music stages and five bars, programming house and techno on the main floor and broader hip-hop and pop on the smaller stages. Open on event weekends rather than nightly.
Tip: Tram to Dělnická is the easy way in. Programming is event-driven so check mecca.cz before turning up.
Duplex sits on the seventh-floor roof of a Wenceslas Square tower, with a glass-cube club and an outdoor terrace that runs through summer and a heated dome through winter. Programming runs house and electronic on the main floor with pop and dance on the rooftop bar.
Tip: The terrace is the draw; arrive before midnight for the city-view bar before the floor packs. Heated dome stays open in winter.
Lucerna Music Bar opened in 1995 in the basement of the Lucerna Palace arcade between Vodičkova and Štěpánská, booking touring indie, rock, hip-hop and electronic acts plus the long-running 80s and 90s video party that fills the room every Friday and Saturday until five.
Tip: Enter through the arcade off Vodičkova; the 80s-90s video party is the easiest weekend ticket. Cloakroom moves fast.
Jazz Dock runs on stilts above the Vltava under the Janáčkovo riverbank, with floor-to-ceiling glass facing the water and two sets nightly across postmodern jazz, soul and acoustic singer-songwriter bookings. The room has run since 2009 and is among Europe's most prolific jazz programmers.
Tip: Two sets nightly, usually 19:00 and 22:00; the late set on Friday and Saturday runs cheaper. Book ahead for named acts.
Reduta has run on Národní since 1957 as Prague's oldest jazz room, with a small stage that Bill Clinton famously played saxophone on during a 1994 state visit. Programming covers swing, mainstream jazz and blues across nightly sets.
Tip: Concert at 21:30 nightly; arrive by 21:00 for seats. Cash door plus card; small cover.