1 hour by trainDirect trains from Prague hlavni nadrazi to Plzen, every 30 minutes
Famous for: Pilsner Urquell brewery tour and Na Spilce beer cellar restaurant
Plzen, 90 km west of Prague, is the birthplace of pale lager. The Pilsner Urquell brewery tour ends in the cellar where unpasteurized lager pours straight from the oak barrel.
1 hour by trainDirect trains from Prague hlavni nadrazi to Kutna Hora, hourly
Famous for: Bohemian wine cellars and the Bone Church
Kutna Hora was a medieval Czech silver-mining city. The Bone Church and St Barbara's Cathedral anchor the day; the Kutnohorske vinarstvi serves local Bohemian wines from old cellars.
2 hours by train or busBus from Prague Florenc to Karlovy Vary, every two hours
Famous for: Becherovka herbal liqueur and spa-town wafers
Karlovy Vary, the western Bohemian spa town, is the home of Becherovka, the herbal Czech aperitif. The Becherovka museum and tasting room sit in the old factory off the colonnade.
3 hours by bus or trainRegioJet bus from Prague Florenc to Cesky Krumlov
Famous for: Vltava trout, riverside restaurants, southern Bohemian beer
Cesky Krumlov is a UNESCO-listed southern Bohemian town. Riverside restaurants on the Vltava grill local trout; Eggenberg Brewery has been pouring 1560-era beer in the castle since the Renaissance.
1 hour by trainTrains from Prague hlavni nadrazi to Benesov, then 2 km walk to Konopiste
Famous for: Game restaurant and Archduke Ferdinand's hunting lodge
Konopiste Castle south of Prague was Archduke Franz Ferdinand's hunting lodge. The castle restaurant cooks game in the old hunting tradition: venison goulash, boar shoulder, pheasant.