Antidote at Chemist Spirits (top floor) is a nightlife spot in South Slope, Asheville.
Antidote's top-floor bar at Chemist Spirits on Coxe Avenue runs as a 1920s apothecary-styled cocktail rooftop above the South Slope. Chemist gin and rum.
Tip: Top floor takes the South Slope views. Distillery tours run downstairs weekends; book ahead.
Address: 151 Coxe Ave, Asheville, NC 28801
The Crow and Quill on North Lexington Avenue is Asheville's hidden speakeasy with 800+ whiskeys and 1,000 spirits. Edgar Allan Poe-meets-1920s aesthetic.
Tip: Look for the 106 and the lanterns; door is unmarked. Small cover for non-members; reservations recommended weekends.
O.Henry's on Haywood Street is Asheville's longtime LGBTQ pub, with drag shows on weekends. After Scandals closed in March 2025, O.Henry's anchors the city's.
Tip: Weekend drag shows from 22:30; pub-style cocktail and beer menu. Walk-in welcoming format.
The Rankin Vault on Rankin Avenue, a one-way downtown alley, opened in 2008 as a cocktail lounge with the Vault Burger served until 02:00 daily.
Tip: Late-night menu kicks in at 23:00. The Vault Burger is the local-cult late-night order.
The Orange Peel on Biltmore Avenue is Asheville's headline mid-size music venue. 1,050 capacity, hosting national touring acts from Bob Dylan to Smashing.
Tip: Buy tickets via the venue website. Standing-room floor; balcony seats are limited and sell first.
5 Walnut Wine Bar on West Walnut Street pairs an eclectic by-the-glass wine list with live music every night: jazz, salsa, blues, Afrobeat. Asheville's.
Tip: Walk-in, no cover. Brass and Afrobeat on weekend evenings; arrive by 19:30 for a seat near the stage.
The Social Lounge above Strada Italiano on Broadway Street is Asheville's original rooftop cocktail bar. Italian-leaning cocktails, covered patio, weekend.
Tip: Walk-up; covered patio works in rain or shoulder season. The rooftop fills first on warm evenings.
