Wiseacre Brewing is a brewery in Downtown, Memphis.
Wiseacre Brewing's downtown Memphis flagship on BB King Boulevard is a 40,000-square-foot brewery with 30 beers on tap and the in-house Little Bettie pizza.
Editorially verified May 21, 2026 by Lewis Vaughan, TableJourney editor. Source.
Tip: Cash-free taproom; card only. Take the Tiny Bomb pilsner to the patio first.
Address: 398 S BB King Blvd, Memphis, TN 38126
Crosstown Brewing Co. on Concourse Avenue next to Crosstown Concourse in Memphis runs a hop-forward American craft program from a purpose-built brewery.
Tip: Beer flights run all week. The taproom is dog- and family-friendly with picnic tables outside.
Ghost River Brewing on South Main in Memphis runs a sustainable craft program named for the section of the Wolf River that vanishes underground.
Tip: Check the taproom calendar for hours; the South Main brewery now runs the full beer list and food.
Soul and Spirits Brewery in the Pinch District of Memphis runs German, Czech and American lagers, British cask ales and nitro pours from a 25-tap house.
Tip: Closed Mondays and Tuesdays. Walk over from Bass Pro Pyramid; small kitchen too.
