45 minutes west by carDrive west on I-64 then Highway 94 along the Missouri River
Famous for: Missouri's oldest wine district, tastings on the bluffs
Augusta was named America's first federal wine district in 1980, and its bluff-top wineries like Montelle pour Norton and Vignoles above the Missouri River.
80 minutes west by carDrive west on I-44 and Highway 19, or take the Amtrak Missouri River Runner
Famous for: A German wine town with the historic Hermann Wine Trail
A German-settled river town, Hermann anchors a wine trail of family wineries including Stone Hill, Missouri's oldest, founded 1847, plus sausage and strudel.
40 minutes west by carDrive west on I-64 then Highway 94 to Defiance
Famous for: A compact cluster of wineries, a brewery and a distillery
A small river-bluff town, Defiance packs several wineries, a brewery and a distillery within a couple of miles, the closest wine country to St. Louis.
30 minutes south by carDrive south on I-55 to the Kimmswick exit
Famous for: The Blue Owl's Levee High Apple Pie in a historic river village
A tiny 19th-century river village south of the city, Kimmswick is home to the Blue Owl Bakery, famous for its Levee High Apple Pie stacked with 18 apples.
1 hour south by carDrive south on I-55 to Ste. Genevieve
Famous for: French Creole history and a cluster of wineries
Missouri's oldest town, Ste. Genevieve preserves 1700s French Creole architecture and sits in wine country, with more than a dozen wineries within its limits.
25 minutes northeast by carDrive northeast on I-55 across the river into Illinois
Famous for: Goshen Coffee and the Cleveland-Heath dining tradition
A college town across the river in Illinois, Edwardsville is home to Goshen Coffee Roasters and a walkable Main Street that anchors the metro-east scene.
1 hour west by carDrive west on I-44, or take the Amtrak Missouri River Runner
Famous for: A riverfront town near the Missouri wine corridor
A historic Missouri River town near the wine corridor, Washington pairs a brick downtown with proximity to the Augusta and Hermann wineries.
20 minutes southwest by carDrive southwest on I-44 to Kirkwood
Famous for: An international grocery and a walkable downtown
A leafy inner-ring suburb, Kirkwood pairs a walkable downtown and farmers market with Global Foods Market, the metro's premier international grocery.