Mixtli is a modern mexican restaurant in Southtown, San Antonio.
Editorially verified May 28, 2026 by Lewis Vaughan, TableJourney editor. Source.
Must order: Whatever region the rotating tasting menu is exploring this season.
Tip: The menu changes every several weeks and focuses on one region of Mexico at a time. Book on Tock well ahead; seats are limited.
Address: 812 S Alamo St Suite 103, San Antonio, TX 78205
Rosario's is a two-storey Southtown Tex-Mex room with a rooftop bar, where enchiladas verdes, fajitas and frozen margaritas anchor a buzzy First Friday crowd.
Order: Enchiladas verdes, fajitas and a frozen margarita on the rooftop.
Tip: Head upstairs to the rooftop bar for downtown views. First Friday in Southtown turns the place into a party.
Chef Jennifer Dobbertin's New Asian American restaurant sits in the historic Mueller House at the Pearl, drawing on her Chinese-American heritage.
Order: Crab rangoon dip, Taiwanese popcorn chicken and the family-style noodles.
Tip: The patio and the funky Mueller House interior are both worth requesting. Cocktails lean playful; ask for the seasonal special.
Chef John Russ and Elise Russ run Clementine in Castle Hills, a chef-driven New American room that has been one of San Antonio's most ambitious kitchens.
Order: The Feed Me tasting option, which lets the kitchen build the meal for you.
Tip: Order the Feed Me option and let the kitchen drive. The dining room is small, so book ahead on OpenTable.
Chef Jeff Balfour's Southerleigh brews 15 beers in-house on the ground floor of the Pearl Brewery and pairs them with Texas coastal cooking.
Order: Fried chicken, Gulf snapper and a pint of the house-brewed beer.
Tip: Sit near the gleaming brew tanks and order the fried chicken with the house pilsner. The patio fills fast on Pearl market mornings.
Ladino is a Sephardic-leaning Mediterranean room at the Pearl built for family sharing, where wood-grilled meats anchor a table of mezze, hummus and lamb.
Order: Wood-grilled meats and mezze from the Sephardic-leaning menu.
Tip: Go family-style across the mezze and let the grill section anchor the table. The hummus and the lamb are reliable openers.
La Fonda on Main is the oldest continuously operating Mexican restaurant in San Antonio, opened by sisters Virginia Berry and Nannie Randall in 1932.
Order: Cheese enchiladas, mole poblano and a margarita on the hacienda patio.
Tip: Ask for a table on the covered patio. The mole poblano is the dish to order if you want something beyond Tex-Mex.
Rosario's is a two-storey Southtown Tex-Mex room with a rooftop bar, where enchiladas verdes, fajitas and frozen margaritas anchor a buzzy First Friday crowd.
Order: Enchiladas verdes, fajitas and a frozen margarita on the rooftop.
Tip: Head upstairs to the rooftop bar for downtown views. First Friday in Southtown turns the place into a party.
