Stellenbosch lies 50 km east of Cape Town and runs the country's first wine route, founded in 1971, with more than 200 producers signed to it.
TipBook one tasting before lunch and one after, and use a driver or a tour: the estates sit on the outskirts of town, a drive apart.
Franschhoek sits 75 km from Cape Town in the valley settled by French Huguenots in 1688, now lined with wine estates, restaurants and a hop on wine tram.
TipBook the Franschhoek Wine Tram ahead, choose one line, and plan lunch at an estate on that line rather than driving between farms.
Paarl is 60 km north-east of Cape Town and the biggest town in the Winelands, built under granite domes with brandy cellars and old cooperative wineries.
TipPaarl is the brandy end of the Winelands. Pair a cellar tour with a late lunch on the Berg River rather than trying to fit two tastings in.
Hermanus is about 115 km from Cape Town, and the Hemel-en-Aarde Valley behind it holds some fifteen small wineries known above all for Pinot Noir.
TipDrive out on the R44 coast road and back on the N2. The valley runs 20 km up the R320, so pick three cellars, not six.
Paternoster is 145 km north of Cape Town, a whitewashed fishing village where the crayfish comes off the beach and the cooking is done over open fire.
TipGo for lunch and order the crayfish the village is known for, then walk the whitewashed fishermen's cottages down to the beach.
Darling lies 75 km north of Cape Town, a West Coast farming village with a craft brewery, a handful of farm kitchens and a wildflower season in spring.
TipTime the trip for the spring wildflowers, then stop at the Darling Brew Tasteroom or Evita se Perron before driving back.