30 miles, about 45 minutes by carUS 1 north to mile marker 30, then follow Watson Boulevard towards No Name Key
Famous for: Pizza and smoked fish dip under a ceiling of signed dollar bills
Big Pine Key hides No Name Pub, a 1931 general store turned 1936 pub where Key West day-trippers eat pizza under thousands of stapled dollar bills.
50 miles, about 1 hour by carUS 1 north to mile marker 49, Gulf side at 35th Street
Famous for: Lobster reuben at a working fish house
Marathon anchors the middle Keys food run from Key West, where Keys Fisheries serves its lobster reuben over the docks beside a working seafood market.
80 miles, about 1 hour 45 minutes by carUS 1 north to mile marker 77.5, bayside
Famous for: Dockside breakfast and tarpon feeding at a Keys marina
Islamorada makes the long day trip from Key West worthwhile: Robbie's marina pairs the Hungry Tarpon's dock breakfasts with hand-feeding wild tarpon.
23 miles, about 35 minutes by carUS 1 north to mile marker 22.5, oceanside
Famous for: Fresh local seafood at a highway-side dining room
Cudjoe Key's Square Grouper Bar and Grill is the Lower Keys seafood stop worth the drive out of Key West, with the My New Joint lounge upstairs.
15 miles, about 20 minutes by carUS 1 north to mile marker 15; the roastery is on the left heading north
Famous for: Roadside coffee roastery and espresso stop at mile marker 15
The Saddlebunch Keys run is Key West's shortest food drive: Baby's Coffee roasts at mile marker 15, the classic halfway stop on any Lower Keys loop.